The Pathogenesis of Dermatitis Herpetiformis
نویسندگان
چکیده
منابع مشابه
Dermatitis herpetiformis.
Dermatitis herpetiformis (DH) is an autoimmune, pleiomorphic, papulovesicular disorder associated with celiac disease and gluten sensitivity. DH is characterized by subepidermal bullae on hematoxylin and eosin staining and granular immunoglobulin A deposits in the dermal papillae using the direct immunofluorescence method. Antibodies to tissue transglutaminase and epidermal transgulatminase can...
متن کاملDermatitis herpetiformis.
Dermatitis herpetiformis (DH), described over 100 years ago, is a life-long blistering skin disease that can appear at any age. Dapsone controls the rash effectively and has been used for over 50 years in the treatment of DH. Major landmark in the research of DH was 30 years ago the discovery of granular IgA deposits in the upper papillary dermis,1 and further differentiation of an autoimmune d...
متن کاملDermatitis herpetiformis and vitiligo.
Dermatitis herpetiformis (DH) is a rare immunobullous disorder of the skin that is associated with gluten hypersensitivity. Subepidermal IgA-type antibody deposition against tissue transglutaminase leads to dense neutrophilic microabscess and eventually into vesicles in dermal papillae, which may occasionally merge into bullae. Being a subepidermal vesiculobullous disorder, DH is frequently ass...
متن کاملReview: dermatitis herpetiformis*
Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. It is an IgA-mediated cutaneous disease, with immunoglobu...
متن کاملDermatitis herpetiformis presenting as intertriginous dermatitis.
A 54-year old man with atypical dermatitis herpetiformis Duhring lasting about three years is reported. The lesions were located exclusively in the pubic area, groins, inner thighs and perianal regions. Routine histopathology and the direct as well as the indirect immunofluorescence supported the diagnosis. Application of a gluten-free diet and dapsone alleviated the symptoms.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1978
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12541202